Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data

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Analysis of Draize Eye Irritation Testing and its Prediction by Mining Publicly Available 2008 - 2014 REACH Data 1

Public data from ECHA online dossiers on 9,801 substances encompassing 326,749 experimental key studies and additional information on classification and labeling were made computable. Eye irritation hazard, for which the rabbit Draize eye test still represents the reference method, was analyzed. Dossiers contained 9,782 Draize eye studies on 3,420 unique substances, indicating frequent retestin...

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Analysis of Draize Eye Irritation Testing and its Prediction by Mining Publicly Available 2008–2014 REACH Data

Public data from ECHA online dossiers on 9,801 substances encompassing 326,749 experimental key studies and additional information on classification and labeling were made computable. Eye irritation hazard, for which the rabbit Draize eye test still represents the reference method, was analyzed. Dossiers contained 9,782 Draize eye studies on 3,420 unique substances, indicating frequent retestin...

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Global Analysis of Publicly Available Safety Data for 9,801 Substances Registered under REACH from 2008–2014

The European Chemicals Agency (ECHA) warehouses the largest public dataset of in vivo and in vitro toxicity tests. In December 2014 this data was converted into a structured, machine readable and searchable database using linguistic search engines. It contains data for 9,801 unique substances, 3,609 unique study descriptions and 816,048 study documents.This allows exploring toxicological data o...

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Analysis of Publically Available Skin Sensitization Data from REACH Registrations 2008–2014

The public data on skin sensitization from REACH registrations already included 19,111 studies on skin sensitization in December 2014, making it the largest repository of such data so far (1,470 substances with mouse LLNA, 2,787 with GPMT, 762 with both in vivo and in vitro and 139 with only in vitro data). 21% were classified as sensitizers. The extracted skin sensitization data was analyzed t...

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ژورنال

عنوان ژورنال: ALTEX

سال: 2016

ISSN: 1868-596X

DOI: 10.14573/altex.1510053